Commercially derived high-expressing stable cell lines
Stable GS (Glutamine Synthetase) knock-out cell line with high productivity, average titer 2-5+g/L.
CLD platform supports Cell line construction, development, Clone screening, Cell banking services for different types of biologics.
Automatic clonal screening equipment (Solentim VIPS™, etc.) to shorten timeline, lower cost and improve efficiency.
High-quality cell culture / downstream purification processes development
Advanced Ambr™ microscale bioreactors to shorten PD timeline, reduce materials and labor cost.
Platform deploys various types of bioreactors with their corresponding process development to meet customers’needs using the state-of-the-art cell culture development equipment.
High throughput protein purification process development equipment (AKTA avant150, etc.) meet the demands for highly efficient downstream process development and sample preparation. Maximum purification efficiency and yield ensured by flexible chromatographic column combinations.
Non-GMP / GMP Pilot (200L / 500L) stock solution production platform
Fully cGMP qualified facility with wide range of CMC development and clinical production capacities meets requirements of biologics manufacturing from US, Europe ,China and other regulatory agencies around the world.
Upstream production line with single-use Sartorius bioreactors (2X200L, 2X500L) and downstream production lines with GE, Pall chromatography systems supports GMP production of biologics.
Drug substance production platform capacity reaches kg-scale, which is sufficient to support clinical declaration and the production of early clinical samples.