Technology

Biocatalysis

Asymchem Technology Enzyme Lab

Cost-effective, Sustainable Approach to Transformation

Our experts can design, optimize and screen enzymes (biocatalysts) based on each project’s specific demands. Biotransformation (enzyme catalysis) is foundational to our manufacturing approach, guaranteed to meet GMP standards, and flexible enough to produce quantities from from mg to ton manufacture. Synthetic route development results in a much more cost-effective and green process, taking advantage of the highly selective nature of enzymes, especially as a replacement of chiral precious metal catalysts.

Available Services

  • Enzyme Screening
  • Enzyme Development
  • Process Development & Optimization
  • Technology Transfer

Immobilization Solutions

We offer a variety of enzyme immobilization solutions with the aim of achieving overall efficiency in integrated biocatalysis. Our immobilization platform is customized for enzymes with the purpose of suitability, scalability, and economies in the manufacturing process and offers the following advantages:

  • Quick and rational design
  • Generic and custom immobilization platforms
  • Single enzymes, multiple enzymes, and co-enzymes/cofactors
  •  Expertise in analysis method development
  • Operational stability testing of immobilized enzymes
  • PBR / CSTR mode of testing
  • Capability from gram to kilo scale

Enzyme Library

Asymchem’s enzyme library includes wild type enzymes in the public domain and enzymes engineered in house. All were produced by expression of recombinant genes. Stocks are continually maintained and replenished.

Enzyme Asymchem Enzyme Library Other Available Enzymes in Class Total
Ketoreductase 182 150 320
Transaminase 347 50 367
Hydrolase
(lipase & esterase)
110 60 121
Amino acid dehydrogenase 60 30 90
Nitrilase 43 68 111
Ene reductases 41 23 64
Monooxygenase 125 96 221
Imine reductase 45 26 71
Ammonia Lyase 40 0 40
Other enzyme 81 104 185
Total 1074 607 1590

Other available enzymes: These samples in the Asymchem collection were obtained from outside sources, including other companies. Some are in the public domain, while others have IP encumbrances associated with their use.  Nevertheless, experiments with enzymes in this group sometimes lead to additions to the Asymchem Enzyme Library or help guide enzyme evolution work with Asymchem enzymes.