API Solutions

Continuous Flow

Productivity Innovation from Reaction to Workup

Asymchem has successfully developed the “end to end” continuous process to replace conventional batch process from reaction to workup. Through the combination of process optimization, modularization, and automation, continuous flow can improve the productivity and quality of pharmaceuticals. Our platform has improved process robustness, reduced chemical waste, and is much better at handling unstable chemicals. Our continuous flow platform has been applied to and improved productivity of multiple key intermediates and API commercial projects of pharmaceuticals — all of which comply with the GMP requirements.

Reaction Types

  • Cryogenic reactions (≤-20 degrees)
  • High temperature reactions (≥150 degrees)
  • Diazomethane reactions
  • Ozonolysis
  • Oxidation with peroxide
  • Nitration
  • Photochemistry
  • Electrochemistry
  • Catalytic hydrogenation reactions
  • Preparation and application of Grignard reagent
  • Hazardous reactions involving azide or hydrazine compounds
  • Reactions with gases (acetylene, ethylene, ammonia, etc.) and more

Capacities

  • From milligrams (mg) to 8 metric tons (mt)
  • 80% waste decrease Rh catalyst

Production Example