Asymchem’s Peptide Biosynthesis Platform
Peptide drugs have many advantages over small molecule drugs and protein drugs, such as strong stability, strong specificity, and weak immunogenicity. The specific advantages of peptides make them unique in drug development and have high clinical value. To assist in the development of peptide drugs, Asymchem has established an efficient peptide synthesis technology platform with microbial expression and two-step purification. The platform has successfully carried out small-scale synthesis of pharmaceutical peptides with a capacity of >300 mg/L, which is much higher than the highest level of 100-120 mg/L reported in the literature.
Asymchem Completes Proof-of-Concept for Cell-free Synthesis
Cell-free synthetic biotechnology is a powerful and flexible cutting-edge technology that is free from the constraints of living cells. It can be used for the design and modification of biological components and systems, with a wide range of applications in the life sciences. It provides a simpler and faster engineering solution than cell-based systems, allowing the freedom to design systems in a non-cellular environment. Asymchem has successfully completed a proof-of-concept cell-free synthesis with a pilot protein yield of 3~4 mg/mL, exceeding the protein yield of ~2 mg/ml.
Custom Developed and Designed Continuous Hydrochloric Acid Hydrolysis Equipment
Asymchem developed and designed continuous hydrochloric acid hydrolysis equipment. The reaction time was reduced to 1/5 of the batch reaction time. The daily processing capacity of each set is 160kg, and it can be used in parallel for easy amplification.
Patent Granted: “A Method of Synthesizing Thiopental Side Chains”
Asymchem’s patent“a method of synthesizing thiopental side chain” was granted (Authorization Notice No. CN109796434B). The method adopts biological conversion steps such as monooxygenase, ketone reductase, etc., effectively reducing the amount of chemical reagents such as ethyl acetate. It can solve the existing technical problems in the synthesis of thiopental side chain which requires a large amount of solvent.
Patent Granted: “Continuous Synthesis Method for Non-Amides”
Asymchem’s patent “Continuous Synthesis Method of Feminamide” was granted (Authorization Notice No. CN109438374B). The continuous synthesis method not only avoids the isomerization step in the conventional route and simplifies the purification step of the final product, but also reduces the process cost and effectively shortens the reaction route; meanwhile, the heat exchange speed of the reaction system in the synthesis device is higher, and the reaction conditions are more violent but safer.