Technology

Flow Chemistry

Sustainable Access to Drug Substance

Over the last ten years, Asymchem’s Chemical Engineering Lab (CEL) has led our flow chemistry service solutions and developed multiple platforms and processes. The resulting mastery of “end-to-end” continuous flow production allows our team of specialized scientists and engineers to fabricate new reactors and develop robust processes to match reaction requirements. These solutions offer customers multiple advantages including improved safety and efficiency, space savings, increased production capacity, and paired with in situ reaction monitoring.

To date, CEL has developed platforms for process screening, equipment especially designed for process validation and prototype reactors. Applying these advances, we’ve been able to easily judge flow reaction feasibility, transfer new technology to production, and scale-up applications quickly — all while applying GMP requirements.

Reaction Types

  • Cryogenic reactions (≤ -20ºC)
  • High temperature reactions (≥ 150ºC)
  • Diazomethane reactions
  • Ozonation reactions
  • Oxidation with peroxide
  • Nitration
  • Photochemistry
  • Electrochemistry
  • Catalytic hydrogenation reactions
  • Preparation and application of Grignard reagent
  • Hazardous reactions involving azide or hydrazine compounds
  • Reactions with gases including acetylene, ethylene, ammonia, etc

Process Development Solutions

  • Flow-chemistry feasibility assessment
  • Process development and optimization
  • Validation and up-scaling
  • Model design (new technology platform)
  • Technical package optimization
  • Technical transfer from lab to plant
  • Continuous improvement
  • Process optimization for all scales – lab, kilo scale, and commercial