Asymchem Green Initiatives

The CDMO of the Future is GREEN.

Every day, Asymchem demonstrates that sustainability, environmental safety, and improving our clients’ bottom line are complementary goals.

Continuous Flow Technology

By applying Continuous Flow technologies in Manufacturing:

  • Energy consumption is reduced by 50%
  • Floor space is reduced by 70% on average
  • Wastes are reduced by 30%-60%
  • Yield is increased by 0%-30%
  • Personnel cost is reduced by 50%-70%

Greener from End to End

Flow Technology

Asymchem has developed an “end-to-end” continuous process to replace conventional batch process from reaction to workup, with:

  • Flow equipment that’s affordable and easy to access
  • Modular design for optimal efficiency
  • Early deployment expertise, cost/benefit customization
  • Phase-appropriate control strategies to mitigate risks

Sustainable Access

Flow Chemistry

For over a decade, Asymchem’s Chemical Engineering Lab (CEL) has led chemistry service solutions developing platforms for process screening, equipment especially designed for process validation and prototype reactors. Applying these advances, we’ve been able to easily judge flow reaction feasibility, transfer new technology to production, and scale-up applications quickly — all while applying GMP requirements.

A Naturally Green Solution

Biocatalysis Technology

Compared to traditional synthetic methodologies, the use of biocatalysis for the manufacture of small molecule active pharmaceutical ingredients is increasingly recognized as a more sustainable alternative, as it can afford superior product quality, reduce environmental impact, and provide access to novel transformations.

  • Requires fewer steps
  • Is more rapid
  • Generates less waste
  • Reduces manufacturing costs
  • Greatly reduces environmental impact

Library of 900+ Enzymes

Asymchem has a comprehensive platform for applying new enzymes to industrial applications.

  • Discovery
  • Screening
  • Evolutionary Modification
  • Immobilization
  • Fermentation of new enzymes to industrial applications

Awards

  • Green Factory | 2017

    Ministry of Industry and Information Technology of China

  • CMO Excellence in Green Chemistry | 2021

    Inaugural award from ACS Green Chemistry Institute Pharmaceutical Roundtable

A Cleaner Way to Create New Molecules

Electrochemistry

By conducting lab-based feasibility studies, we can determine whether a redox can be done electrochemically and whether it’s feasible for scale up. Each scope includes selection of appropriate cathode and anode, electrolyte, and other conditions such as concentration and applied voltage. In addition we can manufacture large quantities using flow cell technology.

Advantages

  • Alternative to traditional reduction/oxidation reagents that are toxic, expensive and not environmentally friendly
  • Access to chemical transformations not traditionally available through typical chemistries
  • Reactivity can be “dialed-in” to achieve improved chemoselectivity
  • Acceleration of redox steps in a complex catalytic cycle possible

Innovating at Light Speed

Photochemistry

Combining Flow technology with Photochemistry benefits from:

  • Better, more uniform irradiation than in batch
  • High efficiency and low side reactions
  • No costly reagents and catalysts
  • Effecient Scale-up
  • Efficiencies further multiplied by flow chemistry capabilities

Continuous reactions include:

  • Ring-opening
  • Photo-redox
  • Photo-oxidation

From Scarcity to Abundance

Non-Precious Metal Catalysis (NPMC)

The precious metals typically used as catalysts in pharmaceutical manufacturing — palladium, platinum, rhodium, and ruthenium — keep costs high and efficiencies low. Working in-house and in collaboration with industry and academic leaders, we wanted to find a better way, so we co-founded the NPMC Consortium. In concert, we’ve developed processes and procedures that use non-precious metal catalysis (NPMC) to challenge cost, abundance, sustainability, and waste inefficiencies.

  • Active research into less expensive catalysts or enzymes for catalysis
  • Ni-catalyzed reductive coupling
  • Extends to heterocycles and functionalized alkyl halides

Recycling when it really counts

Solvent Recovery

Because solvent is almost always the single biggest input in the drug manufacturing process, we’ve focused on optimizing and innovating around solvent recovery. If we can capture, recycle, or reuse solvent we’re increasing process intensification and reducing the environmental impact from operations — even eliminating the need for solvent incineration. Our distillation and unit operations experts ensure the reliable quality of recovered streams. Ultimatelythat also means that our customers are getting the most value out of every input.

  • Capture, Recycle, Reuse Solvents
  • Increase Process Intensification
  • Reduce Solvent Incineration

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