Pilot Validation of Continuous Flow Reaction Device for Key Intermediates of β-lactam Antibiotics
Designed and assembled by Asymchem, β-lactam key intermediates continuous flow reaction device has been fully validated for production. The overall yield is 5% higher while production efficiency increased by 40% compared to conventional batch production process. The annual production capacity of a single set of equipment could reach 13 MT. The production capacity of the equipment could reach 50mt per annual if necessary. In addition, the whole process offers advantages in multiple areas such as safety and efficiency, small footprint, and stable product quality. Since this new technology is highly automated, it results in more than 50% saving on labor costs.
Production Tests of Flow Continuous Methanesulfonyl Azide Preparation Reactor
Designed and assembled by Asymchem , the continuous flow equipment for preparation of methanesulfonyl azide preparation has been successful tested on production scale. A single unit could process and produce 0.5 to 1.2 MT of substrate per day. The new continuous flow equipment offers advantages of optimized mixing liquid phases, simple operation, small footprint with far greater safety, reliability, and consistent product quality compare to conventional batch synthesis.
Asymchem’s Self-developed P450 Enzyme Granted a Patent
Asymchem’s self-developed P450 enzyme was patented by China National Intellectual Property Administration (CN112359027B). Direct transformation of alkenes to the corresponding anti-markovnikov carbonyl compounds has proven difficult. It depends on precious metals performing with both low turnover numbers and regioselectivity/ enantioselectivity. The P450 enzyme and its variants were obtained by enzyme screening and evolution, which can catalyze the anti-markovnikov alkene oxidation with high activity and selectivity. The variants can be used to synthesize important intermediates and simplify the synthesis route.
Asymchem Develops a New Class of Esterases, Obtains Patent
Based on the existing enzyme library and relying on the core technology of the enzyme evolution platform, Asymchem has independently developed a new class of esterases, which have been granted a patent by China National Intellectual Property Administration (CN 112430585 B). With high catalytic efficiency and good stereoselectivity, this class of esterase has solved the problem that it is difficult to synthesize high purity chiral acid (ee value >98%) by chemical synthesis method. Additionally, it reduces waste offering a green chemistry solution.