Technology Updates
Production Test Passed For New Continuous Reaction Device
The continuous Grignard reagent preparation reaction system designed and developed by Asymchem has completed the production test, with the production capacity up to 5-6t/d. The new reaction device has the advantages of a high degree of automation, safety and reliability, and stable product quality.
New and scalable continuous photochemical bromination reaction technology
Asymchem’s photochemical group of CEPS has developed a scalable continuous photochemical bromination technology. The new process could achieve the benzyl monobromo substitution of aromatic or heteroaromatic rings with wide substrate scope, robust function group compatibility and high monobromo selectivity. Compared with the traditional thermochemical free radical bromination reaction process, the continuous photochemical bromination process is safer and more controllable. It avoids the run-away risk of reaction by heat accumulation in traditional thermochemical reactions and also avoids the disadvantages of poor monobrominated selectivity as further reaction of monobromo product due to untimely separation in batch reaction.
Peptide Biosynthesis Technology Platform
Asymchem has successfully established a high-efficiency peptide bio-synthesis and two-step purification technology platform. Compared with the traditional inclusion body expression and denature/refolding method, the new technology adopts a soluble expression strategy. This method simplifies the process and reduces cost. The purity of the target peptide could be reached to 85-90% by one-step precipitation, and further improved by preparative HPLC to 98%. The technology has been successfully applied to several pharmaceutical peptide syntheses on a lab-scale, among them, one peptide has a synthesis capacity of >300 mg/L, higher than the highest level of 100-120 mg/L reported.
Peptide-Drug Conjugates Service Platform
Asymchem started to build a Peptide-drug Conjugates (PDC) CDMO service platform for the past couple of years. The team includes 20+ members, including process chemists, analysts, manufacturing engineers, and a dedicated purification team. The technical advantages of peptide and drug linker synthesis and purification provide technical support for the production of PDC. Both short peptide <10AA and long peptide >10AA can be synthesized by LPPS and SPPS. Asymchem is capable of operating OEL≤0.05ug/m3 compounds and has a USFDA certified manufacturing facility to produce and service high potency APIs for customers worldwide.
Online Particle Track Aids R&D of Crystallization Process
The Crystallization Engineering Laboratory of Asymchem Chemical Engineering Department imported the online particle track with FBRM (Focused Beam Reflectometer) – and set up the crystallization research platform using Easymax (automated reaction and crystallization workstation) + PVM. By monitoring the entire crystallization process, real-time in-situ in-line tracking data of crystal particle changes can be obtained, allowing scientific guides on R&D and production. This ensures that the crystalline products meet quality requirements, process performance, repeatability and stability targets.
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