API Solutions


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From Laboratory to GMP Production

Asymchem’s oligonucleotide technology platform provides clients with pre-clinical sample preparation, oligonucleotide drug substance, and formulation GMP production service. The process, analysis, formulation, and registration regulations teams collaborate to provide clients with a fast, efficient, and flexible integrated solution for oligonucleotide development.

Our oligonucleotide platform is equipped with advanced equipment and technologies including GE ÄKTA oligonucleotide solid-phase synthesizer and purification equipment from gram-scale to kg-scale. In addition, analytical equipment including Qtof, UPLC-MS, UPLC, GPC, and other instruments can provide support for oligonucleotide structure characterization, analysis method development and verification, GMP production IPC control, final product release testing, and stability research.

Service Offerings

  • Various modified or non-modified antisense oligonucleotides
  • RNAi, RNAa
  • Morpholine oligonucleotides
  • Locked oligonucleotides
  • Peptides-oligonucleotide conjugates
  • Self-assembled RNA nanoparticles


  • Integrated experienced team: process, analytical, manufacturing, QC and QA
  • Well-equipped facilities 
  • Integrated service scope: peptide, drug linker, oligonucleotides and the conjugates between them 
  • Reliable and qualified supply chain management system including self-made synthetic capability of key materials and intermediates 
  • Strong support from GMP and EHS compliance
  • Project management system and dedicated project team 
  • Responsiveness to change in project needs 
  • Shorter lead time