API Solutions
Oligonucleotides

From Laboratory to GMP Production
Asymchem’s oligonucleotide technology platform provides clients with pre-clinical sample preparation, oligonucleotide drug substance, and formulation GMP production service. The process, analysis, formulation, and registration regulations teams collaborate to provide clients with a fast, efficient, and flexible integrated solution for oligonucleotide development.
Our oligonucleotide platform is equipped with advanced equipment and technologies including GE ÄKTA oligonucleotide solid-phase synthesizer and purification equipment from gram-scale to kg-scale. In addition, analytical equipment including Qtof, UPLC-MS, UPLC, GPC, and other instruments can provide support for oligonucleotide structure characterization, analysis method development and verification, GMP production IPC control, final product release testing, and stability research.
Service Offerings
- Various modified or non-modified antisense oligonucleotides
- RNAi, RNAa
- Morpholine oligonucleotides
- Locked oligonucleotides
- Peptides-oligonucleotide conjugates
- Self-assembled RNA nanoparticles
Advantages
- Integrated experienced team: process, analytical, manufacturing, QC and QA
- Well-equipped facilities
- Integrated service scope: peptide, drug linker, oligonucleotides and the conjugates between them
- Reliable and qualified supplier chain management system including self-made synthetic capability of key materials and intermediates
- Strong support from GMP and EHS compliance
- Project management system and dedicated project team
- Responsiveness to change in project needs
- Shorter lead time