API Solutions


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From Laboratory to GMP Production

Asymchem’s oligonucleotide technology platform provides clients with full services in drug substance, from process development through GMP manufacturing, and drug product, from preformulation development through fill-finish. The process chemistry, analytical, formulation, and regulations teams collaborate to provide clients with a fast, efficient, and flexible integrated solution for oligonucleotide development.

Our oligonucleotide platform is equipped with advanced technologies including GE ÄKTA oligonucleotide solid-phase synthesizer and purification equipment from gram-scale to kg-scale. In addition, analytical equipment including Q-TOF, UPLC-MS, UPLC, GPC, and other instruments can provide support for oligonucleotide structure characterization, analytical method development and validation, final product release testing, and stability research.


Service Offerings

  • Various modified or non-modified antisense oligonucleotides
  • RNAi, RNAa, mRNA
  • Morpholine oligonucleotides
  • Locked oligonucleotides
  • Peptides-oligonucleotide conjugates
  • Self-assembled RNA nanoparticles


  • Integrated experienced team: process, analytical, manufacturing, QC and QA
  • Well-equipped facilities 
  • Integrated service scope: peptide, drug linker, oligonucleotides and the conjugates between them 
  • Reliable and qualified supply chain management system including self-made synthetic capability of key materials and intermediates 
  • Strong support from GMP and EHS compliance
  • Project management system and dedicated project team 
  • Responsiveness to change in project needs 
  • Shorter lead time